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KMID : 1189420140270030106
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2014 Volume.27 No. 3 p.106 ~ p.114
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Protective Effects of Complex Diet of Korean red ginseng and fish oil on UV-induced Photoaging
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Mun Yeun-Ja
Jeon Byoung-Kook
Lee Jin-Ho
Kim Tae-Hyun
Choi Hyung-Wook
Lim Kyu-Sang
Woo Won-Hong
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Abstract
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Objective : UV irradiatiion causes skin-aging involving coarse wrinkles, thickning, dyspigmentation, and rough skin surface. This study was aimed to elucidate the anti-winkle activity of complex diet of Korean red ginseng (RG) and fish oil (FO) on UV-induced Photoaging.
Methods : To investigated photo-protective effects of Korean red ginseng and fish oil on UV-induced damaged skins, SKH hairless female mice were randomly divided into six groups [control, UV, UV/RG, UV/FO, UV/RG/FO(low), UV/RG/FO(high)]and orally administered three times a week respectively. UV radiation was applied to the backs of the mice three times a week for 8 weeks. Expressions of matrix metalloproteinase (MMP)-3, MMP-13 and tissue inhibitor matrix metalloproteinase (TIMP)-1 in skin were measured by immunohistochemical staining.
Results : In this study, UVB-induced epidermal hypertropy was diminished by RG group or FO group or complex group of RG and FO. Expression levels of MMP-3 and MMP-13 were reduced and expression level of TIMP-1 was increased by RG group or FO group or complex group of RG and FO. Especially MMP-3 and MMP-13 were markedly reduced by diet of FO and complex diet of RG and FO compared with untreated group.
Conclusions : This results suggest that complex diet of RG and FO have a anti-wrinkle activity on UV-induced photo-aging and intrinsic aging.
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KEYWORD
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Korean red ginseng (RG), Fish oil (FO), MMP-3, MMP-13, TIMP-1
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